Calciphylaxis, a rare and serious condition, often associated with end-stage renal disease, is characterized by the calcification of small blood vessels within the body. It can lead to severe skin ulcers and tissue damage, which can lead to infection, sepsis, and even death. The condition is also known by other synonyms, including Calcific Uremic Arteriolopathy (CUA), Coagulative Cutaneous Necrosis, and Uremic Small Artery Disease. Increasing awareness and understanding of calciphylaxis and its synonyms are crucial for early diagnosis and effective treatment, which can improve patient outcomes and quality of life.