Exocrine pancreatic insufficiency (EPI) is a condition characterized by the inability of the pancreas to secrete digestive enzymes into the small intestine. This can result in malabsorption of nutrients and various digestive symptoms. Synonyms for EPI include pancreatic exocrine insufficiency, pancreatic maldigestion, and pancreatic enzyme deficiency. Other related terms may include malabsorption syndrome, steatorrhea (excessive fat in the stool), and diarrheal diseases. EPI can be caused by various factors such as chronic pancreatitis, cystic fibrosis, or pancreatic surgery. Treatment options include pancreatic enzyme replacement therapy and dietary modifications to improve nutrient absorption. Early diagnosis and prompt treatment can help improve quality of life for individuals with EPI.