Howsoever is a conjunction that can be replaced by a range of synonyms that convey a similar meaning. These synonyms include "however," "nevertheless," "yet," "nonetheless," "regardless," and "in any case." Each of these words expresses a degree of contrast or opposition, indicating that despite whatever conditions or circumstances may exist, some other condition or circumstance remains true. For example, if someone were to ask if you were available for a meeting, you could reply, "Howsoever, I have a conflicting commitment," or "However, I have a conflicting commitment," or "Nonetheless, I have a conflicting commitment," etc. In each case, the response conveys the same basic message while using a different word to do so.