Segmental duplication refers to the duplication of large blocks of genomic sequences at specific locations in the genome. Synonyms for segmental duplication include gene duplication, segmental amplification, chromosomal duplication, and tandem duplication. Gene duplication is used interchangeably with segmental duplication and refers to the duplication of a single gene. While segmental amplification refers to the duplication of a certain gene region amplification in multiple copies. Chromosomal duplication describes the duplication of whole chromosomes, while tandem duplication outlines the duplication of a specific sequence within a chromosome but in a tandem arrangement. These terms help geneticists to describe the phenomenon of duplication in the genome in a specific context.