Spleen cancer, a rare but alarming condition, refers to the malignant growth of cells in the spleen. Although there are several types of spleen cancer, awareness and early detection are crucial in combating this potentially life-threatening disease. Synonyms for spleen cancer include splenic neoplasms or malignant tumors of the spleen. These terms indicate the abnormal proliferation of cells within the spleen, leading to a compromised immune system and adverse health effects. Symptoms of spleen cancer may include abdominal pain, fatigue, unexplained weight loss, and an enlarged spleen. Timely diagnosis and medical intervention are imperative to improve outcomes for individuals facing this challenging health condition.