Unacquaintedness refers to the state of being unfamiliar with something or someone. This term can be substituted with related words such as unfamiliarity, ignorance, inexperience, and unawareness. Other synonyms for unacquaintedness include strangeness, novelty, newness, and foreignness. These words all describe a lack of familiarity or knowledge about a particular subject or situation. The opposite of unacquaintedness is familiarity, which refers to being acquainted or well-known with something or someone. In summary, unacquaintedness may be replaced with various synonyms to describe the same concept of being unfamiliar with a subject or individual.