Vacuolate refers to something that is filled with or containing vacuoles. Some synonyms for vacuolate include vesiculate, honeycombed, and cellular. Vesiculate refers to something that is covered with vesicles or small sacs such as those found in a blister. Honeycombed describes something that has a network of small cavities or cells resembling honeycomb. Cellular refers to something that has a structure resembling cells, such as the network of cells in a leaf or the tiny air sacs in the lungs. Other synonyms for vacuolate include porous, cavernous, and hollow, which all describe objects that contain empty spaces or holes within their structure.