Variant Creutzfeldt-Jakob Disease (vCJD) is a rare and fatal brain disorder that affects humans. Its symptoms include rapid cognitive decline, muscle stiffness, and uncontrollable jerking movements. There are several synonyms used for vCJD, including Mad Cow Disease, Bovine Spongiform Encephalopathy, and Transmissible Spongiform Encephalopathy. These terms describe the cause of the disease, which is believed to be the consumption of contaminated beef products. vCJD is different from the classic or sporadic form of Creutzfeldt-Jakob Disease, which occurs spontaneously and is not linked to contaminated food. While vCJD is rare, it remains a serious public health concern, and efforts to prevent its spread continue to be a priority.