Synonyms for Against the grain:

• adj.

  •opposed/opposing (adjective)
  • Denying,
  • antithetical,
  • allergic,
  • disputed,
  • contrary,
  • Combating,
  • Exposing,
  • defending,
  • confronting,
  • enemy,
  • Objecting,
  • Disputing,
  • warring,
  • antonymous,
  • Battling,
  • clashing,
  • crossing,
  • disagreeing,
  • defensive,
  • rival,
  • repelling,
  • irreconcilable,
  • protesting,
  • facing,
  • antipathetic,
  • Controverting,
  • opposite,
  • hostile,
  • conflicting,
  • inimical,
  • averse,
  • Gainsaying,
  • incompatible.
  •oppositional (adjective)
  • adverse,
  • adversarial,
  • antagonistic.
  •unwilling (adjective)
  • indocile,
  • malcontent,
  • shrinking,
  • grudging,
  • uneager,
  • laggard,
  • indisposed,
  • reluctant,
  • involuntary,
  • Against,
  • disobliging,
  • afraid,
  • evasive,
  • recalcitrant,
  • unready,
  • loath,
  • refractory,
  • unaccommodating,
  • shy,
  • compelled,
  • Demurring,
  • slow,
  • resistant,
  • uncheerful,
  • uncooperative,
  • forced,
  • unwishful,
  • remiss,
  • slack,
  • unenthusiastic,
  • disinclined,
  • begrudging,
  • hesitating,
  • unobliging,
  • uninclined,
  • wayward.

• Other synonyms:

  •
  • opposed.
  •Other relevant words:
  • Contrariously,
  • counter,
  • against the wind,
  • upside down,
  • at war with,
  • uninviting,
  • Contra,
  • in reverse,
  • rearward,
  • perverse,
  • at issue,
  • rearwards,
  • cross-grained,
  • on the contrary,
  • unpleasant,
  • arsy-varsy,
  • rather,
  • intolerable,
  • contrarily,
  • up in arms,
  • cross,
  • backwards,
  • oppositional,
  • anticlockwise,
  • to the contrary,
  • against one's will,
  • per contra,
  • topsy-turvy,
  • Arear,
  • unlikable,
  • in hostile array,
  • displeasing,
  • astern,
  • at war,
  • widdershins,
  • away,
  • ass-backwards,
  • unlovable,
  • contrariwise,
  • involuntarily,
  • eyeball-to-eyeball,
  • inversely,
  • uncongenial,
  • in flat opposition,
  • distasteful,
  • back,
  • at daggers drawn,
  • odious,
  • conversely,
  • by contraries,
  • vice versa,
  • against the tide,
  • athwart,
  • oppositely,
  • at daggers,
  • otherwise,
  • at variance,
  • abhorrent,
  • Fro,
  • unwillingly,
  • retrad,
  • backward,
  • dislikable.

Antonyms for Against the grain:

• adj.

  • opposed/opposing
    Aiding, compatible, helping, similar, Assisting.
  • unwilling
    ready, eager, enthusiastic, prepared, willing.