Agenesis of the corpus callosum (ACC) is a rare birth defect in which the corpus callosum, a bundle of nerve fibers that connects the two hemispheres of the brain, fails to develop properly. Some synonyms for ACC include agenesis or dysgenesis of the corpus callosum, congenital absence of the corpus callosum, and callosal agenesis. These terms refer to the same condition with varying degrees of specificity. Individuals with ACC may experience a range of cognitive, neurological, and developmental challenges, such as intellectual disability, seizures, and difficulties with communication and socialization. Treatment for ACC typically involves a multidisciplinary approach and individualized interventions to address the specific needs of each individual.