CPB stands for various terms such as cardiopulmonary bypass or cardiopulmonary bypass machine, extracorporeal circulation, or heart-lung machine. The purpose of a CPB machine is to allow surgeons to perform open-heart surgery safely by temporarily taking over the heart and lung functions. The synonyms for CPB include ECMO (extracorporeal membrane oxygenation), which is used to provide life support to critically ill patients. Other synonyms for CPB machines are heart-lung bypass machine or simply the bypass machine. CPB is an essential element in heart surgeries, and it is crucial to use synonyms properly to communicate and explain this complicated medical procedure to patients and families.