The phrase "deprived of one's wits" refers to someone who has lost their mental faculties or become irrational. Some synonyms for this phrase include "mad," "crazy," "insane," "delusional," "demented," "deranged," "unhinged," and "mentally unstable." These terms all describe a mental state in which someone has lost touch with reality or is experiencing severe psychological distress. They can be used to describe a range of conditions, from temporary episodes of anxiety or depression to serious mental illnesses like schizophrenia. Regardless of the specific context, using these words to describe someone who is "deprived of one's wits" is often considered derogatory and potentially stigmatizing.