Down-and-outer is a term used to describe someone who is destitute and hopelessly desperate. Synonyms for this term include "pauper", "beggar", "homeless person", "miserable person", "derelict", or "wretched individual". Other synonyms include "vagrant", "destitute person", "poor person", "outcast", "castaway," and "dejected person." These terms are often used to describe individuals who have fallen on hard times and are without basic necessities like food, shelter, and clothing. It is important to have a compassionate attitude towards these people as their situation can be temporary and they may just need a helping hand to get back on their feet.