"For God's/Christ's/goodness'/Heaven's/Pete's sake" is a commonly used phrase to express exasperation, frustration or concern. However, using the same phrase over and over may become monotonous and predictable. To add a fresh twist to the expression, you may use some synonyms such as "for crying out loud," "for the love of all that is holy," "for the life of me," or "good grief." These alternatives can add variety to your speech while still conveying the same sentiment. Additionally, you may use the phrase for emphasis, but try paying attention to the context and tone in which it is used.