General paralysis, also known as general paresis, is a neurosyphilis infection that affects the brain and spinal cord. This condition damages the nerves and causes cognitive impairment, difficulty speaking and walking, and emotional instability. Synonyms for the term "general paralysis" include "neurosyphilis," "paresis," "dementia paralytica," "tabes dorsalis," and "progressive paralysis." These terms are used interchangeably in medical circles to refer to the same condition. If left untreated, general paralysis can lead to severe disability and death. It is essential to seek medical attention at the first sign of symptoms to prevent the progression of the disease and improve the patient's quality of life.