Synonyms for Give the old college try:

• v.

  •labor, work (verb)
  • struggle.

• Other synonyms:

  •Other relevant words:
  • endeavor,
  • break one's back,
  • grind,
  • go all out,
  • assay,
  • dig,
  • hassle,
  • give it one's best shot,
  • toil,
  • sweat,
  • break one's neck,
  • attempt,
  • cope,
  • exert oneself,
  • plug,
  • plug away,
  • try one's hardest,
  • offer,
  • scratch,
  • tackle,
  • seek,
  • bend over backwards,
  • have one's nose to grindstone,
  • strain,
  • make every effort,
  • work like a dog,
  • take on,
  • take a crack,
  • hustle,
  • slave,
  • try,
  • strive,
  • take a stab,
  • undertake.

Antonyms for Give the old college try:

• v.

  • struggle
    laze, forget, neglect, idle, withhold, surrender, procrastinate, ignore, be lazy, rest, yield.