When something goes up in smoke, it means that it has completely failed or been destroyed, often with no hope of recovery. Some synonyms for this phrase include to be ruined, to be dashed, to evaporate, to dissipate, to disappear into thin air, to come to nothing, to fall apart, to go awry, and to be unsuccessful. These phrases can be used in a variety of contexts, such as describing failed business ventures, ruined relationships, or failed plans. Regardless of the situation, going up in smoke implies a sudden and sometimes devastating loss, leaving only ashes and regret in its wake.