Guilt-free is a term that describes something that is without remorse, regret, or shame. Its antonym is "guilty," which means being responsible for a wrongful act, feeling self-reproachful, or having a sense of wrongdoing. Another antonym for guilt-free is "guilt-ridden," which suggests feeling burdened with guilt or anxiety. Similarly, "conscience-stricken" is another antonym, describing a state of unease concerning moral behavior. On the other hand, "blameless" and "innocent" are two opposite words that can describe a state of being guilt-free, implying that there is no fault, offense, or wrongdoing involved. Overall, choosing antonyms for guilt-free depends on the context and intention behind the expression.