Antonyms for the phrase "make most of" are "waste," "squander," "neglect," "overlook," and "miss." These words imply a lack of effort or attention towards maximizing opportunities or resources. By neglecting to make the most of opportunities, individuals may fail to reach their full potential or achieve desired outcomes. Squandering resources or overlooking opportunities can also result in financial setbacks or other negative consequences. Consequently, it is essential to avoid these antonyms and focus on making the most of opportunities, resources, and time to lead a prosperous and fulfilling life.