Antonyms for the phrase "makes best of" include "worsens," "ruins," "destroy," "neglect," "ignore," "undermine," "degrade," "impair," "diminish," and "squander." These words indicate negative actions that lead to a worsening of a situation, rather than an improvement. When one makes the best of a situation, they are making efforts to improve it, adapt to it, or work around it, despite its difficulties. However, antonyms indicate actions that harm, diminish or neglect the situation, leading to negative outcomes rather than positive ones. Therefore, it is essential to make the right choices about how one approaches a situation so that they do not end up worsening it.