The word matchups refers to the comparison or pairing of two teams, players or other entities in competition. Antonyms to the word matchups might include mismatch, imbalance, or unevenness, which imply an unequal pairing or competition. Another possible antonym could be disassociation or unconnectedness, representing a lack of comparison or pairing altogether. Other potential antonyms for matchups could be independent or unequal footing, which indicates that one entity may have a greater advantage or disadvantage than the other. Ultimately, antonyms for matchups are words that suggest a lack of equality, symmetry or balance between two entities, which could cause issues or discrepancies during a competition.