The mini-YKKC RNA motif is a four-nucleotide-long RNA sequence that has been identified as a common motif in functional RNAs. This motif plays an important role in RNA structure and function, particularly in ribosomal RNA. Some synonyms used for the mini-YKKC RNA motif include the YKKC motif, the mini-K-turn motif, and the K-loop motif, reflecting its structural features and the diversity of functional RNAs that contain it. The mini-YKKC RNA motif is a promising target for drug discovery and the development of new RNA-based therapies, and its identification in different RNAs could provide important insights into their biological and molecular functions.