The phrase "most affected" implies a significant impact on something or someone. Antonyms, on the other hand, indicate the opposite. Synonyms for "most affected" include "devastated," "overwhelmed," and "ruined," while antonyms include "unaffected," "unscathed," and "untouched." The opposite of "most affected" refers to something that has not been influenced by a particular condition or situation. It can also be described as a state of being secure, protected, or sheltered. In essence, the antonyms for "most affected" indicate a lack of impact or harm, suggesting a positive outcome in various contexts.