Antonyms for the word "most euphoric" include feelings of sadness, dissatisfaction, or despair. Some examples of antonyms include being depressed, downcast or despondent. These feelings can be accompanied by a sense of hopelessness, or a lack of motivation to tackle difficult tasks. When we experience the opposite of euphoria, it can feel as though life has lost its luster, and that happiness is out of reach. It's important to recognize that these feelings are common, and that seeking help from loved ones or a mental health professional can help us overcome them. So, it's important to keep positive and seek for help if you feel downcast.