Most pricked can be replaced with various synonyms depending on the context of the sentence. Some possible substitutes include most irritated, most offended, most provoked, most annoyed, most vexed, most agitated, most incensed, and most exasperated. If one is talking about physical sensation, alternatives could include most pained, most sore, most tender, most throbbing, most sensitive, and most agitated. In contrast, if the context is emotional rather than physical, one could use synonyms such as most hurt, most wounded, most insulted, most humiliated, most disrespected, or most upset. These synonyms provide a variety of options to add variety and clarity to one's writing.