The phrase "most through-and-through" means something that is complete or thorough in every aspect. There are numerous synonyms for this phrase, including "most comprehensive," "most exhaustive," and "most thorough." Other synonyms for the phrase include "most complete," "most all-embracing," and "most definitive." These words can be used interchangeably depending on the context of the sentence. For instance, if one wants to talk about a topic that is well-researched, they can use the phrase "most thorough" or "most exhaustive." In conclusion, there are several synonyms for the phrase "most through-and-through" that can be used in different contexts and situations.