The phrase "most unintoxicated" refers to someone who is not under the influence of alcohol or drugs. There are many synonyms that can be used to describe this state, including sober, clear-headed, lucid, unimpaired, and coherent. Other synonyms that can be used to describe this state include alert, stable, balanced, composed, and level-headed. These words all describe a person who is fully present and aware of their surroundings, and who is capable of making sound decisions. Whether someone is being responsible on a night out or simply living a healthy lifestyle, being unintoxicated is an important state of mind to aim for.