Nihilate is a heavy-duty word that is often used in discussions about destruction, annihilation, obliteration, and erasure. Synonyms for this powerful term include obliterate, annihilate, extinguish, eliminate, erase, and wipe out. Each of these words conveys a sense of absolute destruction, leaving nothing behind. Other similar words for nihilate include exterminate, decimate, neutralize, and eradicate. All of these words are used to describe situations where something or someone is completely eradicated or rendered non-existent. While these words may have slightly different nuances, they all share a sense of finality and irrevocable destruction, creating a vacuum where there was once something or someone.