Perplexingly refers to something that is difficult to comprehend or understand. There are a number of other words that can be used to replace perplexingly, including confusingly, bafflingly, mysteriously, inexplicably, unfathomably, and enigmatically. Each of these words conveys a sense of something that is difficult to understand, and can be used to describe a wide range of different situations and experiences. Whether you are dealing with a complex mathematical problem or trying to make sense of the behavior of someone you know, any of these words can be used to describe the sense of confusion and bewilderment that you may be experiencing.