Perstringe is quite an unusual word, meaning "to limit or restrict severely." While it might not be a particularly common term, there are certainly many synonyms that can be used to convey a similar concept. Some potential alternatives could include "constrict," "constrain," "curtail," "encumber," "hem in," "hamper," "hobble," "inhibit," "restrain," "shackle," or "stifle." Each of these various words has its unique connotations, but they all share the common thread of referring to something that holds back, restricts, or impedes progress or movement in some way.