"Pick of the litter" is a phrase often used to describe the best or most desirable option among a group. Synonyms for this expression can vary depending on the context, but some options include cream of the crop, top choice, prime selection, finest specimen, and choicest example. Other alternatives might include elite pick, premier selection, prize selection, and top-notch option. These expressions all convey a sense of excellence or superiority, and can be useful when describing anything from pets to employees or products. When looking for an alternative to "pick of the litter," any of these synonyms can help convey the same thought with a different turn of phrase.