Pulling up stakes is an idiomatic expression that means to leave a place and move on to something new. There are several synonyms that can be used in place of this phrase, including hitting the road, breaking camp, packing up, and departing. Each of these phrases can be used in slightly different contexts, but all convey the idea of leaving one place and heading elsewhere. Other synonyms for "pulling up stakes" include moving on, migrating, emigrating, and relocating. No matter which phrase is used, the sentiment is the same - it's time to move on and start fresh.