Replenishing is a word that means to refill or to restock. When we talk about antonyms for this word, we are looking for words that describe the opposite of replenishing. There are several antonyms that can be used for "replenishing," such as emptying, depleting, reducing, removing, and exhausting. Emptying means to remove everything from a container or space. Depleting means to use up a resource or reduce its quantity. Reducing means to make something smaller in size or quantity. Removing refers to taking something away from a place, while exhausting means to use all of a resource until it is completely depleted. Using these antonyms can help you express the opposite of what it means to replenish.