"Set the teeth on edge" is a common expression used to describe an agitating or irritating sensation. However, there are several other synonyms that can be used to effectively convey the same meaning. These include "grind one's nerves," "jangle one's nerves," "put one's teeth on edge," "irritate one's nerves," "rub one the wrong way," "get under one's skin," "rile one's nerves," "grate on one's nerves," and "give one goosebumps." Each of these expressions can be used to communicate a similar feeling of discomfort or annoyance, and can help to add variety and color to one's writing or speech.