Complexity, astuteness, sophistication, discernment, savvy, perception, insight, judgment, shrewdness, acumen, intellect, perspicacity, wisdom, erudition, mastery, profundity, sagacity, enlightenment, sagaciousness, intellectuality, intelligence, discerning, and brilliance are antonyms for the word "simple-mindedness." These words highlight the opposite characteristics of being ignorant, unintelligent, unsophisticated, and unsavvy. Someone who possesses these qualities is highly knowledgeable and possesses excellent decision-making abilities. Therefore, antonyms for "simple-mindedness" describe individuals who are highly intelligent, mentally sound, and possess excellent leadership qualities. These qualities help them to make quick and decisive decisions and navigate complex situations and problems with ease.