Simple chancre, also known as primary chancre, is a common term used in medical science to describe an initial lesion that appears on the skin or mucous membrane following an infection with syphilis. This term may have varying synonyms, such as hard chancre, Hunterian chancre, or initial lesion. These synonyms describe the same medical condition but highlight different aspects of the disease. For instance, hard chancre refers to the firm and painless nature of the sore, while Hunterian chancre honors the discovery of syphilis by British physician, John Hunter. However, regardless of the synonym used, prompt and proper treatment of simple chancre is crucial for preventing the spread of syphilis to other parts of the body and to other individuals.