"Take it on the lam" is a colloquial phrase that means to flee or escape from a dangerous situation or law enforcement. There are many synonyms that can be used to convey the same meaning, including "go on the run," "make a break for it," "split," "bolt," or "skedaddle." Other similar phrases include "hightail it out of here," "cut and run," "hit the road," or "escape under the cover of darkness." Regardless of the phrase used, each conveys a sense of urgency and the need to quickly depart a dangerous or compromising situation.