There are a number of synonym phrases that could be used in place of "twisted the knife wound". Some of the most common options include "aggravated the injury", "worsened the damage", "exacerbated the harm", and "made the pain even more intense". Other potential synonym phrases might include "deepened the wound", "inflicted further agony", "reopened the injury", or "made the suffering even worse". Ultimately, the specific synonym that would be most appropriate to use may depend on the context of the situation, the tone of the piece of writing, and the writer's personal preference for language and phrasing.