Vesicular stomatitis is a viral disease that affects cattle, horses, and pigs. There are several synonyms for this condition, including vesicular exanthema, vesicular bluetongue, and vesicular exanthematous disease. Other related terms include vesicular disease, vesicular mouth disease, and vesicular lesions. The symptoms of vesicular stomatitis include the appearance of vesicles, or fluid-filled blisters, on the mouth, tongue, and feet of affected animals. This can lead to difficulty eating and walking, and may cause significant pain and discomfort. The disease is highly contagious and can spread rapidly among animals in close contact with one another. Effective prevention and treatment strategies for vesicular stomatitis include vaccination, strict hygiene protocols, and early diagnosis and treatment of infected animals. By taking these steps, farmers and veterinarians can help to minimize the impact of this disease on livestock populations.