Waterhouse-Friderichsen Syndrome (WFS) is a rare but life-threatening medical condition that occurs because of adrenal gland failure. The adrenal glands do not produce enough cortisol hormone, leading to severe adrenal insufficiency. The symptoms of WFS include fever, vomiting, diarrhea, abdominal pain, and shock. In severe cases, the patient may suffer from multiple organ failure leading to death. There are no specific synonyms for Waterhouse-Friderichsen Syndrome, but it is sometimes referred to as fulminant meningococcemia. Other related terms include meningococcal sepsis, septic shock, and disseminated intravascular coagulation. Early diagnosis and prompt treatment are crucial to avoid complications. Treatment usually involves intravenous antibiotics and fluids to correct fluid and electrolyte imbalances.