Western Equine Encephalitis, also known as WEE, is a viral disease that affects the central nervous system of horses, causing inflammation of the brain and spinal cord. Other synonyms for this disease include Western Encephalitis, VEE, and Venezuelan Equine Encephalitis. WEE is transmitted through the bite of infected mosquitoes and can lead to symptoms such as fever, lethargy, loss of appetite, and weakness in the limbs. Treatment for WEE is mainly supportive, with the focus on managing the symptoms and preventing secondary complications. Vaccination is also available to protect horses against WEE and other related viral infections. Prompt diagnosis and treatment are essential in managing this potentially fatal disease.