Xenografting refers to the process of transplanting tissues or organs between different species. Synonyms for this term may include xenotransplantation, cross-species transplantation, cross-species tissue grafting, and heterografting. The use of xenografts is often necessary in the case of organ transplantation, but it can also be employed in research settings to study human diseases and disorders. While the ability to xenograft may offer certain advantages, such as an increased availability of donor organs, there are also concerns surrounding the potential for cross-species disease transmission. Nonetheless, ongoing research in the field holds the promise of continued improvement in the safety and efficacy of xenografting.