The Zona Pellucida is an important anatomical structure of the mammalian ovum that plays an essential role in the fertilization process. This layer is composed of glycoprotein and surrounds the oocyte, which is the female gamete. Synonyms for the Zona Pellucida include Vitelline Membrane, Ovolemma, and Zona Pectinata. These terms are commonly used in scientific literature to refer to the protective covering that surrounds the egg. The Zona Pellucida has a crucial function in regulating the entry of spermatozoa into the ovum, allowing only one sperm cell to fertilize the oocyte during fertilization. This process is essential for mammalian reproduction, and the study of this structure has significant implications in human infertility research.