The antonyms for the phrase "acts with regard to" could be "ignores," "disregards," "neglects," or "overlooks." These words signify a lack of attention or adherence to something. When someone acts with regard to a particular matter, they are being mindful of it and taking appropriate action. Conversely, when one ignores or neglects something, they are not acting with regard to it, and the consequences could be severe. Therefore, it is essential to act with regard to all matters, big or small, to avoid any negative consequences that could arise due to negligence or disregard.