Depletedness refers to the state of being completely exhausted, drained or worn out due to physical or mental exertion. Antonyms to depletedness are thus words that describe vitality, energy, and stamina. Some of the antonyms for depletedness are rejuvenation, invigoration, vitality, vivacity, robustness, animation, and vigour. These words signify a state of being healthy, energetic and lively. Rejuvenation implies the restoration of youthful vitality, while invigoration describes a process of being refreshed or re-energized after a period of exhaustion. Vitality refers to the state of being able to sustain life, while vigour suggests strength and power. Overall, these words represent the opposite of depletedness and convey a sense of liveliness and vigour.