The term "little guys" refers to individuals or groups who are perceived as small or insignificant in comparison to others. Antonyms for "little guys" include "big shots," "heavyweights," "movers and shakers," and "power players." These phrases describe influential people who have a lot of power, status, and control in their respective fields. Other antonyms for "little guys" include "leaders," "influencers," "pioneers," and "trendsetters," who have a significant impact on society and inspire others to follow their lead. It's important to remember that these terms are subjective and can vary depending on perspective, context, and societal norms.