There are several synonyms for the phrase "make empty," each with a slightly different connotation. One common synonym is "empty out," which implies a more forceful or complete emptying, as if pouring out the contents of a container. Another synonym is "drain," which suggests removing liquid from a container or space. "Clear out" is a similar phrase that can be used to refer to removing all objects or clutter from a space. "Vacate" and "evacuate" both refer to emptying a space of people, while "depopulate" refers specifically to emptying an area of inhabitants or population. Overall, there are many ways to describe the act of making something empty, depending on the context and specific situation.