The antonyms for the word "makes fruitful" are numerous, and can include phrases like "stifles growth," "prohibits advancement," "thwarts progress," "hinders development," "stunts productivity," "obstructs success," "prevents prosperity," and "inhibits flourishing." All of these phrases suggest that something is hindering or blocking the ability for a project, idea, or initiative to grow and prosper. Whether it's a lack of resources, poor leadership, or external factors outside of one's control, these antonyms convey a sense of frustration and difficulty in achieving success. To avoid these negative outcomes, it is important to identify and address obstacles early on in the process.