Most disadvantaged refers to individuals or groups who are encountering hardship, suffering, or are unable to access crucial resources. So, antonyms for most advantaged can include words like disadvantaged, deprived, underprivileged, unprivileged, helpless, unfortunate, impoverished, oppressed, needy, and less fortunate. These words represent the opposite of advantage and indicate the lack of access to opportunities or resources. In society, there is a constant struggle to bridge the gap between the most advantaged and disadvantaged, and recognizing this dichotomy is the first step towards creating a more equitable and just world.