The word 'most appeased' generally implies a sense of satisfaction or contentment. Its antonyms can be words such as discontent, dissatisfaction, annoyance, agitation, displeasure, or unrest. When something does not make us happy or calm, we tend to feel displeased or dissatisfied, rather than appeased. In contrast to being appeased, one might also feel bothered, disturbed, or agitated if they are unhappy or restless about something. When we are discontent, there is no sense of settlement or calm, since it involves a feeling of being unfulfilled or lacking in something. Therefore, the antonyms of 'most appeased' depict the opposite emotions that give rise to feelings of unrest and unease.